Nucleoredoxin regulates the Wnt/planar cell polarity pathway inXenopus
نویسندگان
چکیده
منابع مشابه
The Wnt5/planar cell polarity pathway regulates axonal development of the Drosophila mushroom body neuron.
Axonal development is a fundamental process for circuit formation in the nervous system and is dependent on many cellular events, including axon initiation, elongation, guidance, and branching. The molecular mechanisms underlying these events have been well studied, especially for axon guidance. In the presence of a guidance cue, the polarization of a growth cone precedes the turning response, ...
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Glomerular podocytes are highly polarized cells characterized by dynamic actin-based foot processes (FPs). Neighboring FPs form specialized junctions, slit diaphragms (SDs), which prevent passage of proteins into the ultrafiltrate. The SD protein complex is linked to cytoskeletal actin filaments and mutations in SD proteins lead to a dramatic change in cell morphology; proteinuria is accompanie...
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to the brain and receive high-order commands and inputs from it. That is, much of the planning, computation and execution of stereotypic arm movements are conducted within the arm neural system itself. Accordingly, natural-looking arm extension movements can be generated in amputated arms. This organization may be an optimal solution for the motor control of highly redundant flexible appendages...
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The PAR complex, consisting of the evolutionarily conserved PAR-3, PAR-6, and aPKC, regulates cell polarity in many cell types, including epithelial cells [1-4]. Consistently, genetic manipulation of its components affects tissue integrity in multiple biological systems [5-9]. However, the regulatory mechanisms of the PAR complex remain obscure. We report here that apoptosis-stimulating protein...
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The establishment and maintenance of apico-basal cell polarity is a pre-requisite for the formation of a functioning epithelial tissue. Many lines of evidence suggest that cell polarity perturbations favour cancer formation, even though the mechanistic basis for this link remains unclear. Studies in Drosophila have uncovered complex interactions between the conserved Hpo (Hippo) tumour suppress...
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ژورنال
عنوان ژورنال: Genes to Cells
سال: 2008
ISSN: 1356-9597,1365-2443
DOI: 10.1111/j.1365-2443.2008.01220.x